Westbrook, Thunder top Bulls for 3rd straight win

first_imgOklahoma City Thunder guard Russell Westbrook (0) goes up for a dunk in front of Chicago Bulls guard Kris Dunn, left, and center Robin Lopez (42) in the second quarter of an NBA basketball game in Oklahoma City, Wednesday, Nov. 15, 2017. (AP Photo/Sue Ogrocki)OKLAHOMA CITY — Things are starting to click for the Oklahoma City Thunder.Russell Westbrook had 21 points and seven assists and the Thunder beat the Chicago Bulls 92-79 on Wednesday night for their third straight victory.ADVERTISEMENT Sports Related Videospowered by AdSparcRead Next LATEST STORIES LeBron’s ‘superhuman’ powers will eventually go away, Draymond Green says PH’s Charly Suarez boxing lightweight final (HIGHLIGHTS) PLAY LIST 03:47PH’s Charly Suarez boxing lightweight final (HIGHLIGHTS)02:30SEA Games: Agatha Wong wins 2nd gold medal in wushu00:50Trending Articles02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Jake says relationship with Shaina ‘goes beyond physical attraction’ “In the second half, we never got into a rhythm,” Thunder coach Billy Donovan said. “Never played to an identity. I thought our defense, for the most part, was pretty good for the full 48. We had some lapses. But I thought offensively, that’s where we got to really move the ball and make them work and find ways to break the defense down better than we did in the third and the fourth.”TIP-INSBulls: Were coming off a 133-94 loss to San Antonio. … Starters shot 1 for 11 from the field in the first quarter. … Valentine was the only Bulls player to make more than two field goals in the first half.Thunder: C Steven Adams missed his third straight game with a right calf contusion. … Won the firstmeeting with the Bulls 101-69 on Oct. 28. … Grant made a layup off an inbounds pass in the final second of the first half. … George finished with 13 points after scoring 42 and 37 points in his previous two games.STAT LINESOklahoma City’s wins during the current streak have come by an average of 11.7 points. All of the Thunder’s wins this season have been by at least nine points. All the losses have been by nine or fewer.QUOTABLEWestbrook, on being focused against a struggling team: “We did a good job of just coming out and being consistent, staying with our principles, playing Thunder basketball and not worrying about the opponents.”UP NEXTBulls: Host the Charlotte Hornets on Friday night.Thunder: At San Antonio Spurs on Friday night. Lauri Markkanen and Antonio Blakeney each scored 16 points for Chicago, and Denzel Valentine added 13. The Bulls shot 34.7 percent from the field.“We fought from the second quarter on, but again, we’re down 20 in the first quarter with a seven-point quarter,” Bulls coach Fred Hoiberg said. “You’re not breeding any confidence for yourselves. So it’s a mindset. You’ve got to come out and see that thing go through the hoop. It’s going to give you a little confidence. Right now, we don’t have a lot, especially early in games.”The Thunder led 58-34 at halftime. Westbrook didn’t score until 6:43 remained in the second quarter, but finished the half with 17 points.“He does that to a lot of people,” Hoiberg said. “He’s so explosive. There’s a reason he was the MVP last season.”Though the Thunder were never threatened in the second half, they had hoped to finish better. They shot 22 percent after the break.ADVERTISEMENT MOST READ Kiss-and-tell matinee idol’s conquests: True stories or tall tales? It’s too early to present Duterte’s ‘legacy’ – Lacsoncenter_img Jake says relationship with Shaina ‘goes beyond physical attraction’ Redemption is sweet for Ginebra, Scottie Thompson Don’t miss out on the latest news and information. Oklahoma City had high hopes coming into the season after trading for All-Stars Carmelo Anthony and Paul George, but the Thunder had lost four straight before getting things turned around to even their record at 7-7.“From here, we’re kind of gaining some momentum,” George said. “We’re getting consistency from our level of play standpoint. I think we’re starting to come together for the most part. Again, we’re obviously not where we want to be. There’s always going to be a level of improvement, but we’re trending in the right direction.”FEATURED STORIESSPORTSRedemption is sweet for Ginebra, Scottie ThompsonSPORTSMayweather beats Pacquiao, Canelo for ‘Fighter of the Decade’SPORTSBack on the throneAnthony returned to the lineup after missing the previous game with a sore lower back and finished with 18 points and 11 rebounds. Jerami Grant added 15 points and 11 rebounds.The Thunder led 27-7 at the end of the first quarter to match the fewest points they have allowed in a quarter since the franchise moved from Seattle in 2008. The Bulls made 2 of 16 field goals in the period.“Just setting the tone,” Westbrook said. “Thought we did a good job of being aggressive, using our hands.That’s how we win games.” Coco’s house rules on ‘Probinsyano’ set Jo Koy: My brain always wants to think funny Margot Robbie talks about filming ‘Bombshell’s’ disturbing sexual harassment scene OSG plea to revoke ABS-CBN franchise ‘a duplicitous move’ – Lacson View commentslast_img read more

No. 15 Arizona beats USC to defend Pac-12 title.

first_imgArizona’s Allonzo Trier, left, passes the ball as Southern California’s Jonah Mathews defends during the first half of an NCAA college basketball game in the Pac-12 men’s tournament final Saturday, March 10, 2018, in Las Vegas. (AP Photo/Isaac Brekken)LAS VEGAS — Deandre Ayton dribbled through the sea of red-and-white confetti, bobbing and weaving past cheerleaders and fans. The Arizona big man came upon a security guard, dropped a spin move that left both smiling and headed to the locker room.Ayton’s night at the Pac-12 championship was just as smooth a ride.ADVERTISEMENT It’s too early to present Duterte’s ‘legacy’ – Lacson GALLERY: Barangay Ginebra back as PBA Governors’ Cup kings Ayton had 32 points and 18 rebounds in one of the most dominating performances in Pac-12 Tournament history, leading No. 15 Arizona to its second straight title with a 75-61 victory over Southern California on Saturday night.“The dominance he just put forth, if there’s another player better, I’d like to meet him,” Arizona coach Sean Miller said. “He put his team on his back, played the right way and absolutely was a one-man wrecking crew.”FEATURED STORIESSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSTim Cone, Ginebra set their sights on elusive All-Filipino crownSPORTSAfter winning title, time for LA Tenorio to give back to Batangas folkAyton put on a show along The Strip, bouncing back from a nervous Pac-12 opener against Colorado with two dominating games.The Bahamian big man had 32 points and 14 rebounds in a semifinal win over UCLA and knocked the Trojans (23-11) around like bowling pins in the championship game. Ayton made 14 of 20 shots from the floor and all four of his free throws to lead Arizona (27-8) to its ninth Pac-12 title. Phivolcs records 2 ‘discrete weak ash explosions’ at Taal Volcano LATEST STORIES For the complete collegiate sports coverage including scores, schedules and stories, visit Inquirer Varsity. Kansas tops West Virginia to win Big 12 title UK plans Brexit celebrations but warns businesses may suffer Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew Nueva Ecija warehouse making fake cigarettes raided, 29 Chinese workers nabbed “I was a little starstruck, I wasn’t ready, rushing all of my shots against Colorado, not taking my time,” said Ayton, who matched the Pac-12 freshman record set by UCLA’s Kevin Love with his 23rd double-double. “Coach told me to face up, see what the defense is giving me and that’s what I did.”USC gave Arizona trouble with its zone at times and had a decent offensive night. The Trojans just had no answer for Ayton.“I don’t think you’re going to stop a guy like that, so we just have to try to do our best to contain him,” said Nick Rakocevic, led USC with 13 points. “Although he went off tonight.Both teams fought through adversity to reach the title game.Arizona was twice entangled in a federal investigation into shady recruiting practices. USC was named in the probe as well, leading to sophomore De’Anthony Melton to be ruled ineligible this season.ADVERTISEMENTcenter_img Don’t miss out on the latest news and information. Jiro Manio arrested for stabbing man in Marikina Sports Related Videospowered by AdSparcRead Next The Trojans also have played without Bennie Boatright since Feb. 15, when he suffered a season-ending knee injury, and backup point guard Derryck Thornton missed the semifinals due to an illness.In the title game, USC had success getting into the lane and with its pick-and-roll on offense while giving the Wildcats trouble with its zone.Arizona had success getting to the offensive glass — eight in the first half — and by getting the ball to Ayton, who had 13 points and eight rebounds by halftime.USC led 33-30.“We had a three-point lead at halftime in a Pac-12 championship,” USC coach Andy Endfield said. “That’s what you play for, that’s what you dream about.”But Ayton continued to be a nightmare in the second half and USC went down a big man when Chimezie Metu picked up his fourth foul with 12 minutes left.Arizona took off from there — literally.Rawle Alkins brought the pro-Arizona crowd to a roar with a two-handed dunk over Elijah Stewart and Ayton followed with another dunk to make it even louder, putting Arizona up 53-46.Ayton kept dunking and the crowd kept roaring until the confetti cannons went off.BIG PICTURE Steam emission over Taal’s main crater ‘steady’ for past 24 hours USC: likely locked up a spot in the NCAA Tournament after its semifinal victory, but might sweat a little on Selection SundayArizona: looking like one of the nation’s best teams at just the right time and should get a high seed in the NCAA Tournament.ALKINS’ DUNKAlkins’ dunk over Stewart caused maybe the loudest of the night in T-Mobile Arena and still had Arizona’s players talking long after the game.“It took me a few seconds to realize what happened,” Arizona center Dusan Ristic said. “It was one of the best dunks I’d ever seen in my life.”UP NEXTUSC: will play in the postseason, hoping it will be in the NCAA Tournament.Arizona: will play in the NCAA Tournament, most likely as a high seed. Sea turtle trapped in net freed in Legazpi City View comments MOST READ Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player awardlast_img read more

Aston Villa striker set for shock move to Turkey?

first_img Darren Bent in action for Fulham 1 Aston Villa striker Darren Bent could make a surprise move to Turkish club Konyaspor this summer.Bent’s contract with the Villains expires at the end of this month and the 31-year-old looks destined to move elsewhere after enjoying a successful loan spell with Derby County.The Rams are favourites to sign Bent on a permanent deal but, according to Eurosport TR, Konyaspor are preparing an offer for the former Spurs forward.Bent joined Villa in 2011 but has struggled to hold down a starting berth and has been shipped off on loan to Fulham, Brighton and Derby in the past three seasons.last_img read more

Plan would be costly, and not just in terms of money

first_img AD Quality Auto 360p 720p 1080p Top articles1/5READ MORE11 theater productions to see in Southern California this week, Dec. 27-Jan. 2160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! CALIFORNIA’S excellent preschools are threatened as never before by the pet political initiative of Hollywood personality Rob Reiner. Proposition 82 on the June primary ballot would decimate community preschool providers, lower preschool quality by limiting competition and freedom of consumer choice, leave out the disadvantaged kids who most need preschool, and cost far more than the proponents claim. At a time when our public schools are in disarray and we face chronic budget deficits, we shouldn’t be creating a new, multibillion-dollar preschool bureaucracy. We should instead be fixing the huge problems we have with our current K-12 system. Reiner’s scheme for government-run preschool would put the decisions as to which preschools survive or are shut down into the hands of the black hole of California public schools, the county offices of education, a layer of bureaucracy that most voters don’t even know exists. Covetous of more power and operating outside of meaningful voter oversight, the county offices of education will shut down thousands of community-based preschools that currently enroll nearly half of all children enrolled in preschool in California, replacing thriving schools that provide jobs and tax revenue with government-run preschools of much lower quality. Reiner’s notion of “preschool for all” is really preschool for the rich. According to an analysis by respected former Legislative Analyst William Hamm, only 8.4 percent of funding from the new taxes would go to enroll high-risk kids who otherwise wouldn’t have gone to preschool. All the rest of the money is a subsidy of rich kids whose families can now pay anyway. Since so few new poor kids would come into the system, as contrasted with the many kids whose parents now pay and who would be taxpayer-subsidized with Proposition 82, the cost to the taxpayers of each new child coming into the system is an astounding $26,262! Proposition 82 would mean not just low quality and preschool for the rich, but also runaway costs. The Canadian province of Quebec enacted a similar scheme eight years ago, projecting that it would cost $320 million over five years. In fact, it has now cost $8.5 billion over the same period, or 33 times as much, while delivering shoddy preschools with little freedom of choice. All of these various stupidities would be bad enough under any circumstances, but one of the biggest blunders of all is that Proposition 82 is a constitutional amendment. Thus, as it becomes clear how badly it is working, it will be almost impossible to change. Even aside from all of the many problems in the initiative itself, Proposition 82 should be soundly defeated to teach a lesson in ethics and democracy to the people running the campaign. Rob Reiner and his employees last year used $23 million in taxpayer money for TV political ads promoting his vision for universal preschool. He and his cronies may yet be handed criminal indictments for using tax money for politics, but even if they’re conduct was technically legal, many voters will want to send them an unmistakable message in June about not picking the pockets of us taxpayers for politics. At a time when our public schools are in such terrible condition, we cannot afford to divert attention from K-12 education and undermine the quality of our excellent community preschools. The defeat of Proposition 82 is critical to the future of our state, and crucial to the lives of our children. Alan Bonsteel, M.D., is author of the book “A Choice for Our Children: Curing the Crisis in America’s Schools.”last_img read more


first_imgIreland’s second oldest person has died just three months short of her 107th birthday.Bridget ‘Biddy’ Mc Gee, 106, from Mín na Craoibhe, Annagry, West Donegal passed away at Dungloe District Hospital today Saturday.by Eoin McGarvey The great-great grandmother was admitted to the hospital over a week ago but prior to that she remained in reasonable health.Biddy was hale and hearty all her life and on her 106th birthday last October she partied the night away at the nearby Leo’s Tavern.She still collected her pension at Annagry post office up until a few months ago and often went shopping and to the bank in Dungloe.Biddy always maintained her secret to a long healthy life was early to bed, early up in the morning and a daily glass of milk. She would always celebrate her birthday with a glass of Baileys. In 2002 Biddy battled flood waters that threatened her home but was not left wanting as she took a mop and bucket and helped clean up the mess.Despite her big age she always exercised her right to vote in elections and referendums but because of sore bones she did not vote in this year’s referendum.Funeral arrangements to be confirmed.She is survived by two sons and one daughter.The oldest person in the country at present is Mary Kate Byrne, of Maganey, Co Laois, who will be 108 on August 14th. IRELAND’S SECOND OLDEST PERSON DIES IN DONEGAL was last modified: July 14th, 2012 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)last_img read more


first_imgCross Border Anti Drink Driving Campaign – An Garda Síochána in partnership with the Police Service of Northern Ireland this week launched a major joint Anti Drink Driving Campaign, which will continue until January 2014. The launch took place near Belleek on the Donegal/Fermanagh border. The launch demonstrates continued cooperation between the Garda and PSNI in the area of road safety and particularly in the enforcement of Drink Driving legislation on both sides of the border. from left are Brian Richardson, PCSP, Jamie Gallagher, Road Safety Officer Donegal County Council, Garrett Monaghan, Traffice Corp, Inspector Stephen Hasslett, Senior Sergant Joe Hannigan, Inspector Michael Harrison, traffic Corp., Niall Sherran, Traffic Corp, Cllr. Harry Rutherford and Stephen Lambert, RSA. Photo Clive WassonThe head of the Garda Traffic Corps in Donegal has warned that some people continue to drink and drive on the county’s roads.Inspector Michael Harrison was speaking at the launch of the Anti-Drink Driving Campaign which will continue until January 14th.Inspector Harrison revealed that almost double the number of people have been killed on Donegal roads so far this year compared to last. A total of 12 people have lost their lives up until yesterday compared with just 7 for all of last year.Speaking at the launch in conjunction with his PSNI colleagues, Inspector Harrison warned ““A minority of drivers continue to selfishly ignore all the advice that has been offered in relation to drink driving.“Therefore, I wish to remind all drivers that the Gardaí will be increasing our focus over the festive period to ensure that anyone drinking and driving will be arrested and could face a court appearance and disqualification from driving.“Enforcement of the drink-driving legislation remains a major priority as part of our ongoing commitment to reducing road casualties.” The Milford-based Garda admitted that over the years he has witnessed some very tragic scenes in Donegal.“It is often the same when we are called to fatal accidents. People not wearing seatbelts, speeding and people drinking and driving.“It is so frustrating to arrive at the scene of a fatal accident and to realise that people have lost their lives and a family has lost a loved one because people continue to make these mistakes,” he said.The launch took place near Belleek on the Donegal/Fermanagh border.The launch demonstrates continued cooperation between the Garda and PSNI in the area of road safety and particularly in the enforcement of Drink Driving legislation on both sides of the border. The campaign is backed by the Donegal Road Safety Working Group (DRSWG) as part of their ongoing road safety awareness programme. Stephen Lambert, Chairman of the DRSWG said, “If you’re going out this Christmas with friends, make the most of the festive season, but don’t chance drinking and driving. Leave your car at home and don’t risk your life and the lives of others.”The Donegal Road Safety Working Group has also issued the following advice to road users especially over the festive period.DriversDrive at a safe speed appropriate to the changeable wintry conditions Do not drink and drive and don’t let others drink and drive. Use an alternative form of transport or appoint a designated driverEnsure that all passengers – front and rear – are wearing a seatbeltDrive with dipped headlights even during day light hoursWhen it is safe to do so always pull in to the road side to use a mobile phoneMake sure your vehicle is in good working order, i.e. your lights and brakes are in good working order and your tyres are the proper tread depth (1.6 mm)Pre-plan your journey home and take frequent breaks to avoid driving when tiredPedestrians, CyclistsWear bright clothing or reflective material such as a high visibility vest to be safe and be seen by driversRemember drunken pedestrians are also a danger to themselves. If necessary make arrangements to get home safely if you are planning to walk home after a trip to the pub.ROAD DEATHS IN DONEGAL ALMOST DOUBLE THIS YEAR AS GARDAI ISSUE DRINK-DRIVE WARNING was last modified: December 14th, 2013 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:donegalInspector Michael Harrisonroad deathslast_img read more

Magical McElhinneys Christmas windows to be unveiled this Sunday

first_imgMcElhinneys of Ballybofey are set to unveil their much-anticipated Christmas windows this Sunday afternoon. A fantastic family day out is planned for this special event and plenty of surprises are expected.From 3-5pm, Ballybofey will be a festive celebration of music, family fun, prizes and entertainment. An enchanted magical forest came to life in the stunning window display of 2016, while something even more creative, cultural and colourful is expected this time.McElhinneys Christmas Windows – 2016Over 20 McElhinneys team members, as well as many others in the staff force, helped put together an adventurous display in recent weeks. The planning, designing and creating began as far back as January.The secret theme was inspired by all the travels of the McElhinneys team, with inspiration arising from key fashion trends of the season.A wonderful crowd of families and friends are expected to come together this Sunday and admire the beautiful product of all their hard work. McElhinneys Christmas Windows – 2016McElhinneys have also collaborated with the local Chamber of Commerce this year, so the Twin Towns lights switch-on will coincide with the unveiling.The event is set to be a great community gathering full of festive spirit. Mr Claus is said to be arriving in time for the magic moment too! Magical McElhinneys Christmas windows to be unveiled this Sunday was last modified: November 17th, 2017 by Rachel McLaughlinShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:MCELHINNEYSlast_img read more

Are you ready for cleaner petrol?

first_img8 December 2005From the beginning of 2006, all leaded petrol will be phased out in South Africa and new octane grades introduced.Unleaded petrol has been available to South African motorists since 1996. The use of unleaded has gradually increased to comprise about 40% of total petrol sales.Lead was first introduced into petrols in the 1920s, but in recent years there has been a move away from leaded petrol. Lead in petrol contributes to urban pollution and is a health risk, particularly for young children.Lead replacementMotorists will still have the choice of two grades of petrol, although the octane grades will differ between the coast and high-altitude inland stations.Premium, or super, will be replaced with the new Lead Replacement Petrol (LRP), with an octane grade of 95 at the coast and 93 inland.Unleaded petrol will be available in 91, 93, 95 octane grades. Petrol stations are likely to sell only one grade of unleaded, with the higher octanes being used in coastal areas.Vehicle databaseAlthough most modern cars already use unleaded petrol, drivers of pre-1996 cars should check whether their cars will run on the new fuels.The National Association of Automobile Manufacturers (Naamsa) has prepared a database where motorists can quickly look up their vehicle’s make and model to determine which fuel will be suitable. Naamsa database Most older cars should have no problem running on LRP. Cars built more than 20 years ago may need to use an additional bottled additive which will protect their engines.Pre-1996 cars in the coastal region may need to have their timing adjusted in order to run efficiently on LRP. Motorists can check whether their vehicle is affected by consulting the Naamsa database. The timing adjustment can be done at many service stations in the coastal region, and will be a free service.Petrol priceIn the inland area, where the 95 octane unleaded grade will become available for the first time, a special “demand management levy” will be introduced. Initially this grade will priced about 10c per litre higher than the 93 octane.The price for all other grades will be determined using the same method as previously.SouthAfrica.info reporterlast_img read more

Maharashtra’s agricultural market reforms may disrupt open market trade

first_imgMaharashtra’s new agricultural market reforms look to disrupt open market trade scenario by better management of inventory and infrastructure instead of regulating the Minimum Support Price (MSP), according to a report submitted to the State Cabinet. The reforms, part of the efforts to streamline the existing MSP regime, include opening up of MSP procurement centres, effective management of the inventory of the procured food grains and incurring losses by off loading the same in open market. All of this to “further disrupt” the open market trade scenario, officials said. The government has said in the note it does not believe in the knee-jerk action of regulating the MSP but maintains faith in the potential of the tool in changing cropping patterns, fulfilling the goal of food security,and import substitution, among other benefits. “We have closely analysed the impact of the MSP-driven marketing policy on the agriculture marketing reforms. We do not, unlike others States, recommend a knee-jerk reaction to regulating the MSP regime,” a senior official said. The note highlights the State Government’s concerns over lack of transparency in the Agriculture Produce Market Committees (APMCs), which even when governed by the APMC Act are taken over by a “nexus of agents and traders”. “The markets have been taken over by this nexus between traders and commission agents known as Adhatiyas,” the note reads. Among others steps the State Government has already taken a lead providing for an electronic trading platform at the APMCs, developing source of consistent supply of uniform quality raw material for food processing units and meeting specific market requirements including exports, the note says. Earlier last month, the government had dismissed as “misleading”, reports on its plans to jail traders found buying farm produce below the MSP. It had said Maharashtra Cabinet members had, on August 21, discussed a proposal to impose strict penalties for the violation of the Statutory Minimum Price (SMP) under the Agricultural Produce and Livestock Marketing (Promotion and Facilitating) Act, 2017. Nearly 300 Agriculture Produce Market Committees (APMCs) across Maharashtra were tense over the reports, but the government had denied these reports.last_img read more

Male Scent May Compromise Biomedical Research

first_imgJeffrey Mogil’s students suspected there was something fishy going on with their experiments. They were injecting an irritant into the feet of mice to test their pain response, but the rodents didn’t seem to feel anything. “We thought there was something wrong with the injection,” says Mogil, a neuroscientist at McGill University in Montreal, Canada. The real culprit was far more surprising: The mice that didn’t feel pain had been handled by male students. Mogil’s group discovered that this gender distinction alone was enough to throw off their whole experiment—and likely influences the work of other researchers as well.“This is very important work with wide-ranging implications,” says M. Catherine Bushnell, a neuroscientist and the scientific director of the Division of Intramural Research at the National Center for Complementary and Alternative Medicine (NCCAM) in Bethesda, Maryland, who was not involved in the study. “Many people doing research have never thought of this.”Mogil has studied pain for 25 years. He’s long suspected that lab animals respond differently to the sensation when researchers are present. In 2007, his lab observed that mice spend less time licking a painful injection—a sign that they’re hurting—when a person is nearby, even if that “person” is a cardboard cutout of Paris Hilton. Other scientists began to wonder if their own data were biased by the same effect. “There were whisperings at meetings that this was confounding research results,” Mogil says.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)So he decided to take a closer look. In the new study, Mogil told the researchers in his lab to inject an inflammatory agent into the foot of a rat or mouse and then take a seat nearby and read a book. A video camera trained on the rodent’s face assessed the animal’s pain level, based on a 0- to 2-point “grimace scale” developed by the team. The results were mixed. Sometimes the animals showed pain when an experimenter was present, and sometimes they seemed just fine. So, on a hunch, Mogil and colleagues recrunched the data, this time controlling for whether a male or a female experimenter was present. “We were stunned by the results,” he says. The rodents showed significantly fewer signs of pain (an average of a 36% lower score on the grimace scale) when a male researcher was in the room than when a female researcher—or no researcher at all—was there.Thinking back to his Paris Hilton experiment, Mogil wondered whether the rodents were responding to the sight of a woman or man or to something more subtle. So he told the people in his lab to place their worn T-shirts near injected animals and then leave the room. Even when the humans weren’t present, the results were the same. Rats and mice showed about a 36% lower score on the grimace scale when exposed to male versus female T-shirts, the team reports online today in Nature Methods. (Female mice were slightly more sensitive to the effect.) Placing a woman’s T-shirt next to a man’s T-shirt negated the impact. Bedding material from unfamiliar male mice and guinea pigs, as well as pet beds slept in by unsterilized male cats and dogs, produced the same response: Male odors seemed to act like painkillers.Further testing showed that the rodents exposed to male odors were actually feeling less pain, rather than simply hiding the pain they were in. The male aroma ramped up their stress levels, which deadened the hurt. “It’s really astounding that such a robust effect could have been missed for so many years,” Mogil says.He suspects the rodents are reacting to scent chemicals that male mammals have produced for eons. “It’s a primordial response,” he says. “If you smell a solitary male nearby, chances are he’s hunting or defending his territory.” If you’re in pain, you’re showing weakness.Almost every animal behavior studied in the lab, from the effectiveness of experimental drugs to the ability of monkeys to do math, is affected by stress, notes Paul Flecknell, a veterinary anesthesiologist at Newcastle University in the United Kingdom who researches ways to alleviate pain in animals. “This could have an impact on just about everything.”Male odor could even influence human clinical trials. If a male doctor injects you with a new kind of pain medication, do you feel better because of the drug—or because of his gender? “It’s not an unreasonable concern,” Flecknell says.The findings may also suggest why some labs have trouble reproducing the results of other groups. “Sometimes pharmaceutical companies can’t replicate preclinical work,” says Bushnell, who came to NCCAM to develop a pain research program. “This could help explain that.”Still, Mogil doesn’t think scientists need to redo decades of animal research. “It’s a confounding factor, but not a fatal one,” he says. But going forward, he advises, researchers should pay more attention not to just what experiments they’re doing, but also to who’s doing the experiments. “I joke that the solution is to fire all the male researchers,” Mogil says. “But at the very least, this is something teams should be noting in the methods sections of their papers. We can change the bath water without throwing out the baby.”last_img read more